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Triptans (e.g. Imitrex): Oxygen: Caffeine

Calcium Channel Blockers: Ergotamine: Methysergide: Anticonvulsants: Bipolar Disease Drugs: Antipsychotic Drugs: Prednisone

Aborting a CH Attack


  From MAGNUM - Treatment and Management - Cluster Headache - "Sumatriptan 6 mg subcutaneous: Effective in 90% of patients for 90% of their attacks; Efficacy within 15 minutes in up to 75%;... Intranasal sumatriptan or oral triptans are less efficacious."

General Triptan Information

  Teri Robert gives an overview of the use of triptan medications.

Pharmacokinetics and pharmacodynamics of the triptan antimigraine agents: a comparative review

  Article by Jhee SS, Shiovitz T, Crawford AW, Cutler NR. California Clinical Trials, Beverly Hills 90211, USA. found in Clin Pharmacokinet 2001;40(3):189-205...

"Welcome to O2-THIS WORKS!!"

  was compiled from various Internet sources and input from CH sufferers. This site provides a comprehensive guide to using oxygen as a cluster headache abortive.

The author states, "We members of this family (of cluster headache sufferers) are not doctors, but we know what works and we are trying to give you good information and tools that you may use to help with your pain..."

The first section offers a description of the equipment needed. Another provides links to professional medical sources and some tips from several users based on their personal experience. There is information for users to print out to show to doctors who are not familiar with this treatment. Note the guide to traveling with oxygen. It discusses the rules and regulations of various public carriers and how to work with them. And be sure to read the page about using oxygen safely.


The National Headache Foundation (NHF) provides links to several articles concerning headache and caffeine. On their start page type "caffeine" in the search box.

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Preventing CH Cycles/Attacks


The information about CH offered by the Mayo Clinic is comprehensive and very informative. The Mayo Clinic article called Cluster Headache contains a number of sections - two of which are treatment of CH and prevention of CH attacks and cycles.


General information from Infomed.

Calcium Channel Blockers

  From Raymot's International Generic-Brand Dictionary - This chart lists generic names and their brand names in the US, UK, Australia, Canada, and South Africa.

eMedicine Journal Emergency Medicine > Toxicology: Toxicity, Calcium Channel Blocker

  "Calcium channel blocker overdose is rapidly emerging as the most lethal prescription drug ingestion. Overdose by short-acting agents is characterized by rapid progression to cardiac arrest. Overdose by extended-relief formulations results in delayed onset of arrhythmias, shock, sudden cardiac collapse, and bowel ischemia..."


Methysergide (Sansert)

  Why methysergide and sumatriptan are used for different aspects of treatment.

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Gabapentin (Neurontin)

  From MedicineNet.com - This is an anticonvulsant primarily intended to treat seizures (epilepsy).

Valproate Sodium

  From Doctor's Guide - "Valproate Effective In Stopping Persistent Migraine" By Cameron Johnston - "Certain intractable, persistent migraines that do not seem to respond to most anti-migraine therapies may be treated successfully with a drug commonly used to treat some forms of epilepsy..."

Note: "Valproate Use Linked With Metabolic Bone Disease in Young Adults" according a report presented at the American Epilepsy Society meeting in Philadelphia.

Note: The Canadian Journal of Neurological Sciences 1998; 25: 252-253 - "Pathological Laughter Following Intravenous Sodium Valproate"

Topiramate (Topamax)

   Topamax is an antiepileptic drug used to reduce the frequency of seizures, particularly among patients who are not controlled by other antiepileptic drugs (AEDs).

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Bipolar Disorder Medication

Divalproex sodium (Depakote)

   Depakote is used to treat bipolar disorder and is sometimes prescribed for cluster headache and migraine sufferers.

Antipsychotic Medication


  An antipsychotic agent sometimes helpful in preventing cluster headache.



  Deltasone - Complete information on this brand of prednisone.

Last modified: March 2008

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